Long-term central vascular access devices (CVADs), implanted ports or external tunneled catheters (Hickman-Broviac or similar catheters), provide reliable access for administration of drugs, blood products, parenteral nutrition, or blood sampling in patients undergoing treatment of malignancy. However convenient these devices may be, their use may be associated with complications that healthcare providers must be aware of to ensure their best management. The occurrence of unexpected complications, especially infections and mechanical obstructions, may represent serious and unpleasant adverse effects for the patient, which may eventually require the removal of the device. Flushing and locking CVADs with anticoagulant solutions in the intervals between infusions are often included in the maintenance policy to prevent occlusion, although controversy exists over the most appropriate and safe approach. ​